Clinical implications of neuropsychiatric systemic lupus erythematosus
نویسندگان
چکیده
منابع مشابه
Clinical implications of neuropsychiatric systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an auto immune disorder mediated by the immune complex and characterised by its protean clinical mani festation and multisystemic involvement (Mak 2007a). Neuropsychiatric manifestation of SLE (NPSLE) is one of the major and most damag ing presentations. It comprises a wide range of neurological syndromes affecting the central, peripheral and autonomic ne...
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Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been s...
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The authors critically review the literature describing the varied neuropsychiatric syndromes associated with systemic lupus erythematosus (SLE). Factors that have complicated the identification and treatment of affective, behavioral, and cognitive disturbances in these patents are identified, and the utility of various diagnostic interventions is examined. Finally, the authors outline the role...
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C1q deficiency is a rare immunodeficiency, which is strongly associated with the development of systemic lupus erythematosus (SLE). A mutation in one of the C1q genes can either lead to complete deficiency or to low C1q levels with C1q polypeptide in the form of low-molecular weight (LMW) C1q. Patients with C1q deficiency mainly present with cutaneous and renal involvement. Although less freque...
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Patients with systemic lupus erythematosus (SLE) can be affected by a multitude of neurologic and psychiatric symptoms with a wide range of prevalence and severity. Irrespectively from attribution to SLE or other causes, neuropsychiatric (NP) symptoms strongly impact short-term and long-term outcomes, thus NP evaluation during routine clinical practice in SLE should be undertaken regularly. The...
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ژورنال
عنوان ژورنال: Advances in Psychiatric Treatment
سال: 2009
ISSN: 1355-5146,1472-1481
DOI: 10.1192/apt.bp.108.005785